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Active Pharmaceutical Ingredient 99% purity Entecavir /CAS 142217-69-4

World Caring Limited
World Caring Limited
City: Suzhou
Province/State: Jiangsu
Tel: 86-512-68087375
Contact Person:
Ms. Alli Yu

Active Pharmaceutical Ingredient 99% purity Entecavir /CAS 142217-69-4

Place of Origin : China, Enticavir
Brand Name : World Caring, active pharmaceutical ingredient
Certification : COA
Model Number : C-045
MOQ : 1g
Price : negotiable
Packaging Details : Aluminum Foil Bag for 1kg, 25kg per fiber drum
Delivery Time : 7days
Payment Terms : T/T, Western Union, Paypal
Supply Ability : 5000kgs per month
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Active Pharmaceutical Ingredient 99% purity Enticavir /CAS


142217-69-4


Specifications:


Name:Enticavir

Synonyms : 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

Molecular Formula : C12H15N5O3

Molecular Weight : 277.28
CAS:142217-69-4


Uses:


Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a nucleoside analog (more specifically, aguanosineanalogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. The drug's manufacturer claims that entecavir is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It also helps prevent the hepatitis B virus from multiplying and infecting new liver cells. Entecavir is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection.


Certificate of Analysis


Items

Specifications

[Description ]

It should be white or whitish crystalline powder, odorless and tasteless, very slightly in water, slightly soluble in methanol and insoluble in ether.

Specific rotation

Should be between +24°~+28°

[Identification]

(1) HPLC

Retention time of the principal peak obtained from the test solution should be identical with that of the reference solution.

(2) IR

IR spectrum of samples should be identical with that of the reference standard.

[Test]

pH

Should be between 5.5~7.5

Related substances

(1)Total impurity

Should be 0.3%max

(2)maximum single impurity

Should be 0.1%max

Enantiomer

Should be 0.2%max

Methanol

Should be 0.3%max

Dichloromethane

Should be 0.06%max

N- hexane

Should be 0.029%max

Tetrahydrofuran

Should be 0.072%max

N,N-dimethylformamide

Should be 0.088%max

Toluene

Should be 0.089%max

Water

Should be between 5.8%~6.5%

Residue on ignition

Should be 0.1%max

Heavy metal

Should be 20ppmmax

Assay

98.0%~102.0%(C12H15N5O3) calculated on anhydrous basis


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